Ageing Spreads Through The Bloodstream
New research reveals that aging isn’t just a local cellular process—it can spread throughout the body via the bloodstream. A redox-sensitive protein called ReHMGB1, secreted by senescent cells, was found to trigger aging features in distant tissues, impairing regeneration and muscle function. Blocking ReHMGB1 with antibodies in mice reduced cellular aging markers and improved physical performance after injury. These findings identify a key molecular messenger of systemic aging and offer a promising therapeutic target to slow or reverse age-related decline.
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