Sunday, October 5, 2025

Protein ReHMGB1 Implicated in Ageing

Ageing Spreads Through The Bloodstream

New research reveals that aging isn’t just a local cellular process—it can spread throughout the body via the bloodstream. A redox-sensitive protein called ReHMGB1, secreted by senescent cells, was found to trigger aging features in distant tissues, impairing regeneration and muscle function. Blocking ReHMGB1 with antibodies in mice reduced cellular aging markers and improved physical performance after injury. These findings identify a key molecular messenger of systemic aging and offer a promising therapeutic target to slow or reverse age-related decline.


Anti-Aging Breakthrough: Stem Cells Reverse Signs of Aging in Monkeys

Chinese scientists have genetically engineered stem cells capable of rejuvenating the health, including the cognition, of aged macaques.

https://www.nad.com/news/anti-aging-breakthrough-stem-cells-reverse-signs-of-aging-in-monkeys


Wednesday, October 1, 2025

AI energy consumption

Massive data centres that consume huge amounts of energy are springing up everywhere.  Can this really be the right approach to AI, when the human brain consumes a mere 20 watts?

To be honest, I've been surprised that the more-or-less brute-force approach has got as far as it has. I can't help but feel that it's a little inefficient, and that emulating the way nature does things would pay dividends.  But let's pursue this a little more.

I asked my "go to" AI (currently Claude Sonnet 4.5) to compare the energy cost of educating a human for 25 years (PhD-level education) with the energy cost of training current AI models.  "This is a fascinating comparison!" exclaims Claude enthusiastically, always keen to flatter me, making me feel that I've had a brilliant idea that no-one else has ever thought of. Perhaps Claude in reality finds it incredibly tedious as he (it?) has already had the same or a similar discussion with hundreds or thousands of humans. But if he does find it tedious, he's good at hiding it.

Yes, I'm anthropomorphizing Claude to a ridiculous degree, but then I do the same with Google, and it's "Let's ask Mr. Google" from me if there's ever any discussion the requires factual information in order to resolve it. 

Claude informs me that GPT-3 was estimated to use around 1.287 GWh of energy during training, and that current frontier models such as GPT-4 probably use 10 to 100 times more. The human brain consumes 20 watts, and over 25 years that's 4.38 MWh, which is less than the energy used to train GPT-3 by a factor of circa 300.

Claude claimed that the brain does other things than just learning (processing sensory input, controlling the body's muscles and movement, etc.). On the other hand, everything else the brain does is merely operating the body that the brain inhabits.  If we take the possibly-controversial view that the body is merely a support system for the brain - that the sole function of the human is to achieve human-level intelligence and learning - then in fact we need to consider the energy consumption of the entire human, not just the brain. This is around 5 times more, and over 25 years is about 21 MWh

And then, as Claude pointed out, we also need to consider "the massive energy infrastructure supporting human learning - schools, universities, transportation, food production for the learner, teachers' energy consumption, etc. The total societal energy cost of educating a human is orders of magnitude higher."

I asked Claude how to go about estimating the energy cost per human of all the educational infrastructure - including not just schools and universities, teachers and professors, but also libraries and educational book publishing. It came up with a ball-park figure of 800 to 900 MWh.  Almost egging me on in my exploration, it helpfully offered to refine this estimate by looking for more specific data for a particular country. Sure, I said. Let's look at just the US.  "Great! Let me get more specific data for the US ..." it said, eagerly going off to do my bidding. If my humaniform robot is as eager and compliant when I get one, I'll be in heaven.

So it found data for the energy consumption of schools and universities, and the number of enrolled students, and on this basis came up with a much lower figure of 44 MWh, but admittedly not including the energy consumption of teachers and staff, or transport of students to and from school, or libraries and publishing, as well as the amortized cost of constructing educational buildings in the first place. I asked it to do its best to estimate and add in all of these items, and it finally produced a neat, itemized table (below) with a grand total of 139 MWh, which consists of 21 MWh for "human metabolism", and 118 MWh for the per-human cost of the whole educational infrastructure. So the initial 800-900 MWh estimate may have been too high. On the other hand there are no doubt things I've missed with the itemization approach. 

At each stage of the process, Claude added, unbidden, "key insights". Notably, the energy cost of "staff" is surprisingly small, because each teacher is shared between many students.  Transportation of the human to and from school during the K-12 years is a significant fraction of the total educational energy cost, and "private vehicle drop-offs" are particularly energy-intensive compared to taking a school bus.

So now in conclusion it looks like training GPT-3 is equivalent to the complete 25-year education of 9.3 humans, so not so unreasonable after all.  GPT-4 training cost is likely more by a factor of 10 to 50.

Finally we need to consider that the human with a PhD-level education will generally be an expert in only one area, while the latest AI models appear to be rapidly approaching PhD-level expertise in basically all areas of human knowledge, so that you would need a small army of PhDs to compete with AI models on something like the so-called Humanity's Last Exam. The latter (which is an appalling name) is a can of worms that is probably worthy of an entire separate blog entry. Watch this space.

The upshot is that we do appear to be getting "value for money" (or at least, "value for megawatt-hours") from the huge training costs of the latest AI models.






Wednesday, September 17, 2025

How to fix Europe

With 27 member states, the EU is perceived to be unwieldy, bureaucratic and slow to make decisions, and although the European Parliament is democratically elected, the European Commission and the European Council are not.  And the member states retain veto power on important issues.

How would I fix this, if I could wave a magic wand and make things happen?  (Note: This are rough ideas, and this is a work in progress.)

1) There must be a President of Europe, directly elected by all European Citizens.

2) There are far too many member states, and the states have too much power.  First, I would eliminate the veto, and have all issued decided by qualified majority voting.  Second, there are too many small states, and trying to discuss and decide things with all 27 states represented at the top table is basically hopeless.  This will only get worse when Serbia, Albania etc. are admitted, which I hope will be soon. The small states simply have to be grouped together so there are at most ten seats at the top table.  I propose doing this as follows:

  • Give the Benelux countries (Belgium, Netherlands, Luxembourg) one seat.
  • Combine the Nordic countries (Denmark, Sweden, Finland) with Estonia and Latvia. Get Norway and Iceland to join as soon as possible and put them in this group too.
  • Combine the former countries of the Austro-Hungarian Empire (Austria, Czechia, Slovakia, Hungary, Slovenia, Croatia, Bosnia-and-Hercegovina, and Romania).
  • De-balkanize the Balkans! Serbia, Montenegro, Kosovo, North Macedonia, Albania, Bulgaria get one seat. Greece and Cyprus will have to go into this group too.
  • Hopefully the UK will come to its senses and quickly re-join.  UK and Ireland get one seat.
  • Poland and Lithuania, which share a lot of history and culture, get a single seat.
  • Spain and Portugal, likewise, get a single seat.
  • Malta will come under the auspices of Italy.
  • Germany gets a seat to itself.
  • So does France.
3) There are far too many official languages.  There should be one Latin-based language, one Germanic language, and one Slavic language. To avoid giving even more power to states that already have large populations, let's pick Portuguese, Swedish and Slovakian. There's no point making English an official language, as everyone already speaks that unofficially.

4) There must be a European Constitution or at least a Bill of Rights.  The abortive attempt at a Constitution in 2003 was a massive 335-page tome, which perhaps exemplifies the worst of European bureaucracy.  Contrast that with the US Constitution, which was originally written on four sheets of parchment, and is short enough that every American school child can read it and understand it.  But to my mind it's the Bill of Rights that's the most important thing.  What is the EU for, if not to defend the rights and freedoms of its Citizens?  So maybe for now just take the US Bill of Rights, translate it into the three official languages as above, and ship it!

5) Replace the European Commission by a  US-style Executive Branch.  Have the President of Europe nominate a Cabinet, whose members are confirmed by the European Parliament, similarly to the way the USA does it.

6) A single European Army and a single European Border Force instead of 27 separate armies and customs agencies.

I think that just about does it, for now.

Wednesday, April 23, 2025

Transferring from Tumblr

I had a blog on Tumblr that I started on 2023-02-14.  Decided to move here to give it a more conventional blog-like appearance. Not a great fan of the fact that blogspot is integrated into Google now as they already know far too much about me. But, c'est la via, n'est-ce-pas.

  

Protein ReHMGB1 Implicated in Ageing

Ageing Spreads Through The Bloodstream New research reveals that aging isn’t just a local cellular process—it can spread throughout the body...